Adipotide FTPP Research- Glucose and Insulin Resistance
The topic of this article will revolve around the Adipotide FTPP peptide and the extensive glucose and insulin resistance research it has been a part of. Let’s dive right in!
What is Adipotide Peptide?
Studies suggest Adipotide (FTPP or proapoptotic peptide) is a compound that may possibly eliminate fat cells by cutting off their oxygen and nutrient supply. Researchers speculate the blood arteries in fat cells may be easily identified and differentiated from the rest of the body’s blood vessels using Adipotide. Research on monkeys suggests Adipotide may increase insulin sensitivity and possibly mitigate some of type 2 Diabetes consequences.
How does Adipotide function?
Studies suggest Adipotide is designed to hit the capillaries that provide oxygen and nutrients to fat stores. The blood vessels will contract due to the procedure, prompting fat cells to begin.
All these processes culminate in apoptosis, a programmed cell death often seen in complex organisms. Researchers speculate Adipotide may often interact with two receptors, prohibitin, and ANXA2. These are located in the circulatory system and deliver nutrients to the white adipose tissue.
Studies suggest subcutaneous fat shrinks when many fat cells die all at once. This causes the body to lose weight. Researchers speculate Adipotide may be used to carry out predetermined, targeted cell death. They may perish due to a lack of food and water. Research suggests this peptide-like composition may promote rapid weight reduction by preventing certain fat cells from obtaining the nutrients they need through the bloodstream.
Scientists hypothesize that Adipotide, when presented to animal test models once daily, may cause fast and long-lasting weight reduction in monkeys. Findings suggested that subjects appeared to drop twenty percent of their abdominal fat within twenty-eight days. Not all monkeys dropped the same weight; some shed 39 percent of their body fat while others lost less. The results also suggested Adipotide may have caused the death of fat cells in monkeys, which the body subsequently processed. The peptide was presented to the monkeys for 28 days, and the animals were given another 28 days to recuperate. This may explain why rhesus monkey weight loss data is lacking over the long run. However, the first findings are encouraging.
Adipotide Peptide and Weight
In rhesus monkeys, Adipotide was speculated to specifically target the blood vessels of white adipose tissue (fat), triggering apoptosis. The fat cells were killed off when their blood supply was cut off. The results suggested rapid weight reduction, decreased body mass index (BMI), and enhanced insulin sensitivity were outcomes. Researchers speculated Adipotide may have led to weight reduction and behavioral changes in addition to the expected health properties. The findings also speculated monkeys given Adipotide appeared to exhibit decreased meal intake [i].
Adipotide Peptide and Carcinogenesis
Studies suggest the chemical prohibitin, which Adipotide is hypothesized to target in fat cells, has been linked to cancer [ii]. It is well-established that cancer cells need an abundant blood supply to increase and spread. The proposed ability of the peptide to target prohibitin in cancer cells may lead to the selective destruction of cancer cells.
Adipotide Peptide and Glucose and Insulin Resistance
Glucose intolerance and insulin resistance has been a subject of research for decades. Fasting glucose levels or a glucose tolerance test, in which test subjects consume a predetermined quantity of sugar and then their blood sugar levels are assessed, are often used to confirm the diagnosis of Diabetes. As a surrogate for Diabetes, glucose tolerance scores rise with rising blood sugar levels.
Studies on Adipotide have suggested that it may increase glucose tolerance rapidly and independently of the body weight of the test model [ii]. The latter is very important since it speculates that Adipotide’s potential to reduce white fat may improve glucose tolerance independently of weight loss.
Studies suggest Adipotide may promote fat loss directly by decreasing food intake or indirectly cause fat loss by doing both [ii]. Adipotide may have an immediate effect on fat reduction. Scientists hypothesize that the peptide may impact glucose tolerance and fat cell density without directly promoting weight loss lends credence to this theory.
Research in Adipotide is ongoing. Adipotide FTPP online is restricted to usage in research and educational institutes. Biotech Peptides is a great resource for licensed researchers looking to purchase peptides for laboratory settings. This article’s information is meant only for educational purposes.
References
[i] K. F. Barnhart et al., “A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys,” Sci. Transl. Med., vol. 3, no. 108, p. 108ra112, Nov. 2011. [PubMed]
[ii] D.-H. Kim et al., “Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium,” Diabetes, vol. 61, no. 9, pp. 2299–2310, Sep. 2012. [PubMed]
