QPR have sacked manager, Mark Hughes after 10 months in charge with the club bottom of the Premier League.
"The circumstances we find ourselves in have left the board of directors with very little choice but to make a change," read a club statement.
Former Tottenham boss Harry Redknapp is favourite to take over at Loftus Road.
But Redknapp told BBC Sport fans would have to "wait and see" if he is the new boss, adding that he had received no personal contact from QPR.
The club said they are "working actively to put a new managerial structure in place as soon as possible".
Assistant manager Mark Bowen and coach Eddie Niedzwiecki will take charge against Manchester United on Saturday.
Hughes's final match in charge was a home defeat by fellow strugglers Southampton.
"This decision has been taken after careful consideration by the board of directors, following numerous meetings over the last few days," the statement added.
"The board of directors wish to thank Mark for his commitment, hard work and dedication in his 10 months in charge.
"Mark has shown integrity and professionalism throughout his time."
The Hoops only managed to preserve their Premier League status on the final day of last season. After securing survival in May Hughes said: "There is no way we will be in this situation again in my time here."
But, despite a massive overhaul during the summer, the team have continued to struggle.
The arrivals at QPR have included keeper Julio Cesar, defender Jose Bosingwa, midfielders Esteban Granero, Park Ji-sung and Stephane Mbia, as well as strikers Djibril Cisse and Bobby Zamora.