Man United players mob van Persie after he scored
Manchester United will play West Ham United at Upton Park in one of four all-Premier League clashes in the third round of the FA Cup.
Southampton welcome holders Chelsea, QPR host West Brom and Arsenal visit Swansea in the other top-flight ties.
Manchester City will play Watford, while Tottenham entertain Coventry in a repeat of the 1987 final, reports the BBC.
Non-league Harrogate or Hastings will play Middlesbrough, while Lincoln or Mansfield will welcome Liverpool.
The ties will take place on Saturday 5 and Sunday, 6 January 2013.
Manchester United thumped the Hammers 6-0 in their last FA Cup meeting back in January 2003, but the Londoners enjoyed the better of it when the two teams were reunited in the League Cup quarter-finals in November 2010, winning 4-0 at Upton Park.
More recent memories surround Arsenal's meeting with Swansea, with the Welsh side beating the Gunners 2-0 in the Premier League on Saturday.
Matt Rhead's last-minute equaliser in the 3-3 second-round draw with fellow Blue Square Bet Premier side Lincoln City means that Mansfield could yet welcome seven-time winners Liverpool to the One Call Stadium.
Blue Square Premier side Hereford will entertain Everton if they emerge victorious from a replay with League Two Cheltenham Town.
Further down the Football League pyramid, a visit to the Riverside to play Championship side Middlesbrough is at stake when Harrogate Town of the Blue Square Bet North and the Isthmian League's Hastings replay after Saturday's 1-1 draw in the second round.
Boro's fellow Championship high-flyers Crystal Palace may fancy their chances of making up a division's difference when they welcome Premier League Stoke to Selhurst Park.
Brighton will host out-of-form Newcastle at the Amex Stadium while Bolton are at home to Sunderland and Blackpool travel to Fulham.
The draw, conducted by former Tottenham defender Ledley King and ex-Bolton midfielder Fabrice Muamba, also threw up a set of intriguing meetings between Championship sides.
Leeds, winners of the tournament in 1972, will play Birmingham while Burnley face the trip to Barnsley.
Elsewhere Bristol City travel to Blackburn and Charlton take on Huddersfield.