Arsenal manager, Arsene Wenger (L) with Alex Ferguson of Manchester United
Arsenal will face Championship club Blackburn in the FA Cup fifth round at the Emirates Stadium, while Manchester United will host Reading in an all-Premier League clash.
Manchester City will welcome Leeds, which knocked out Tottenham on Sunday, to the Etihad Stadium, while Liverpool's conqueror Oldham will face another Merseyside club in Everton, reports Goal.com.
If it can beat Brentford at the second attempt, Chelsea will face a trip to Middlesbrough in the last 16, while giant killer Luton, which knocked out Norwich, will play Millwall at Kenilworth Road.
MK Dons, which also put out a Premier League club in QPR, will face Barnsley at home while the winners of the replay between Huddersfield and Leicester will play Wigan.
That means the tie between Premier League leader United and struggling Reading is the only one to feature two top flight clubs after a weekend of surprise results.
On Friday, Aston Villa was dispatched by Millwall, before MK Dons and Luton sprung shocks away to QPR and Norwich respectively.
Their triumphs were followed on Sunday by Brentford's draw against Chelsea at Griffin Park and Oldham's 3-2 victory over Liverpool.
The fifth round fixtures will take place over the weekend of February 16 and 17.
FA CUP FIFTH ROUND DRAW
Huddersfield or Leicester v Wigan Athletic
MK Dons v Barnsley
Oldham v Everton
Luton v Millwall
Arsenal v Blackburn
Manchester City v Leeds
Manchester United v Reading
Middlesbrough v Chelsea or Brentford