Super Eagles and Chelsea duo Mikel Obi and Victor Moses will face Czech Republic side Sparta Praha in the UEL round of 32 fixtures held on Thursday.
The Stamford Bridge outfit found themselves playing in the UEL after failing to qualify for the knock out stage of the UCL.
Chelsea came third in group E with 10 points behind Juventus and Shakhtar Donetsk who both made it through to the knock out phase of the UCL, reports futaa.com.
Their host for the first leg encounter Sparta Praha qualified for the round of 32 fixtures having come second behind French side Lyon with nine points.
Chelsea FC will begin their bid to become only the fourth side to have won all three of UEFA's major club competitions away to AC Sparta Praha after the draws for the UEFA Europa League rounds of 32 and 16.
The Blues are seeking consolation after becoming the first UEFA Champions League holders to be knocked out before the turn of the year.
They have met Sparta before securing a win and a draw in the UEFA Champions League group stage, but the round of 32 will be largely a voyage into the unknown – only four other sides have met before in UEFA competition.